Restoring Vision to the Blind: The Lasker/IRRF Initiative for Innovation in Vision Science.

Restoring Vision to the Blind: Project Background and Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . i Restoring Vision to the Blind: Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Chapter 1 Restoring Vision to the Blind: The New Age of Implanted Visual Prostheses . . . . . . . . . . . . . . . . 3 Chapter 2 Restoring Vision to the Blind: Optogenetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 Chapter 3 Restoring Vision to the Blind: Gene Therapy for Vision Loss: The Road Ahead . . . . . . . . . . . . . 23 Chapter 4 Restoring Vision to the Blind: Stem Cells and Transplantation . . . . . . . . . . . . . . . . . . . . . . . . 33 Chapter 5 Restoring Vision to the Blind: Endogenous Regeneration . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 Chapter 6 Restoring Vision to the Blind: Neuroprotection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48 Chapter 7 Restoring Vision to the Blind: Advancements in Vision Aids for the Visually Impaired . . . . . . . . 54 Chapter 8 Restoring Vision to the Blind: Evaluating Visual Function, Endpoints . . . . . . . . . . . . . . . . . . . . 63 Restoring Vision to the Blind: Concluding Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 Appendix 1 Joint Advisory Board and Collaborating Executives Appendix 2 Steering Committee Appendix 3 Participants